The association between mitochondrial DNA copy number, telomere length, and tubal pregnancy

Growing evidence has shown a link between the occurrence of ectopic tubal pregnancy (TP) and the status of oxidative stress (OS), in which the mitochondria and telomeres play an important role. However, little is known about the underlying correlation between TP and the number of copies of mitochondrial DNA (mtDNAcn) or telomere length (TL) abnormalities. In this study, we found the OS level increased in patients with TP.

We hierarchical detect relative mtDNAcn and NE of the villi of normal pregnancy (NP) and TP samples according to different gestational age, fetal sex, maternal age, and BMI. The results showed that the relative mtDNAcn significantly lowered in the villi in the TP group compared with the NP group, which is negatively correlated with the status of the OS. In the NP group, which mtDNAcn the subgroup of women was apparently lower than in the subgroup of men, while there was no statistical difference was found in mtDNAcn in TP group between subgroups of women and men. Additionally, TL relative in TP group were on the same level with the NP group, and there was no statistical correlation was observed between the relative NE and OS level. In summary, our findings suggest that abnormal levels mtDNAcn than TL correlated with TP, which provides new insight into the mechanism of the TP.


local chicken population is a major source of food in rural areas of Algeria. However, as long as they have not been marked. The purpose of this study was to assess the genetic diversity and origin mother domestic chicken of five areas of agro-ecological Algeria West: beach (CT), terrain inland (IP), plateau (HL), mountain (MT) and sahara (SH, including Oasis, Req and Erg region). A set of 88 mitochondrial DNA (mtDNA) D-loop sequences including me hypervariable regions (HV1) were analyzed. Of 397 bp D-loop sequences, 20 variable sites defined 13 haplotypes were identified in the Algerian domestic chicken. Haplotype and nucleotide diversity was estimated as 0.597 and 0.003, respectively.

Phylogenetic and tissue analysis showed two clades or haplogroups (A and E). Only one clade A haplotypes were observed exclusively in the mountains of the population, while, Clade E haplotype is found in almost all chicken Algeria with twelve different haplotypes. These findings show that Algeria chicken came from haplogroup most everywhere that has its roots in the Indian subcontinent. Our results provide important information about the origin of chicken North-West Africa and a historical spread of the first chicken population to the African continent.

 The association between mitochondrial DNA copy number, telomere length, and tubal pregnancy
The association between mitochondrial DNA copy number, telomere length, and tubal pregnancy

Massively parallel single-cell genotypes of mitochondrial DNA and chromatin profile

Natural mitochondrial DNA (mtDNA) mutations allow the inference clonal relationships between cells. mtDNA can be profiled along with measures cell state, but has not been coupled with massively parallel approach is needed to address the complexity of human tissue.

Here, we introduce a high-throughput, mitochondria droplet-based single-cell assay for chromatin transposase accessed by sequencing (scATAC-seq), a method that combines high confidence mtDNA mutation called thousands of single cells with their simultaneous high quality accessible chromatin profile. This allows the inference mtDNA heteroplasmi, clonal relationship, the state of cells and accessible chromatin variation in individual cells. We reveal the single-cell variation in mtDNA heteroplasmi of pathological variants, which we associate with chromatin intra-individual variability and clonal evolution.

Mitochondrial DNA Isolation Kit

K2117-1 1 kit
EUR 686
Description: Isolates mt. DNA, no genomic DNA contamination

Mitochondrial DNA Isolation Kit

K2117-50 50 assays
EUR 718.8

Mitochondrial DNA Isolation Kit

K280-50 each
EUR 705.6

Mitochondrial DNA Isolation Kit, Catalog: PI-0105

PI-0105 50 isolations
EUR 465
  • N/A
Description: To isolate intact mitochondrial DNA from a variety of cells and tissue types without contamination from genomic DNA. 

Mitochondrial Protein Isolation Buffer

22050010-1 30 mL
EUR 76.34

Mitochondria Isolation Kit

AR0156 1 kit
EUR 127.2

Cell Mitochondria Isolation Kit

abx090630-50100tests 50-100 tests
EUR 309.6
  • Shipped within 5-10 working days.

Cell Mitochondria Isolation Kit

ETF3601 100 assays
EUR 135

Cell Mitochondria Isolation Kit

abx090630-100l 100 µl
EUR 187.5

Cell Mitochondria Isolation Kit

abx090630-1ml 1 ml Ask for price

Cell Mitochondria Isolation Kit

abx090630-200l 200 µl Ask for price

Yeast Mitochondria Isolation Kit

K259-50 each
EUR 502.8

Tissue Mitochondria Isolation Kit

abx090631-50100assays 50-100 assays
EUR 309.6
  • Shipped within 5-10 working days.

Tissue Mitochondria Isolation Kit

ETF3606 100 assays
EUR 135

Tissue Mitochondria Isolation Kit

abx090631-100l 100 µl
EUR 187.5

Tissue Mitochondria Isolation Kit

abx090631-1ml 1 ml Ask for price

Tissue Mitochondria Isolation Kit

abx090631-200l 200 µl Ask for price

Mitochondria Isolation Kit (Cultured Cells)

K1138-10 10rxns
EUR 28
Description: Mitochondria Isolation Kit

Mitochondria Isolation Kit (Cultured Cells)

K1138-20 20rxns
EUR 44
Description: Mitochondria Isolation Kit

Mitochondria Isolation Kit (Cultured Cells)

K1138-30 30rxns
EUR 56
Description: Mitochondria Isolation Kit

Mammalian Mitochondria Isolation Kit for Tissue

abx098857-50rxns 50 rxns
EUR 493.2
  • Shipped within 5-10 working days.

Mammalian Mitochondria Isolation Kit for Tissue

abx098857-100l 100 µl
EUR 912.5

Mammalian Mitochondria Isolation Kit for Tissue

abx098857-1ml 1 ml Ask for price

Mammalian Mitochondria Isolation Kit for Tissue

abx098857-200l 200 µl Ask for price

Mitochondria Isolation Kit (Mammalian cells / tissues)

P507L NULL Ask for price

Mammalian Mitochondria Isolation Kit for Cultured Cells

20-abx098856
  • Ask for price
  • Ask for price
  • 2 rxns
  • 50 rxns
  • Shipped within 5-10 working days.

Mammalian Mitochondria Isolation Kit for Cultured Cells

abx098856-100l 100 µl
EUR 912.5

Mammalian Mitochondria Isolation Kit for Cultured Cells

abx098856-1ml 1 ml Ask for price

Mammalian Mitochondria Isolation Kit for Cultured Cells

abx098856-200l 200 µl Ask for price

Mitochondria Isolation Kit for Tissue and Cultured Cells

KC010100 1 kit
EUR 357

Mammalian Mitochondria Isolation Kit For Tissue & Cultured Cells

K288-50 each
EUR 502.8

Minute TM Mitochondria Isolation Kit for Mammalian Cells and Tissues(50 Tests)

MP-007 each
EUR 535

Minute TM Mitochondria Isolation Kit for Muscle Tissues/Cultured Muscle Cells (50 Tests)

MM-038 each
EUR 535

Urine DNA Isolation Kit

K5011150 1 kit
EUR 261

Stool DNA Isolation Kit

K5011250 1 kit
EUR 261

Serum DNA Isolation Kit

K5018100 1 kit
EUR 391

Saliva DNA Isolation Kit

AG0226 Kit Ask for price
Description: Saliva DNA Isolation Kit provides a fast and simple spin column procedure for isolating high quality DNA from saliva samples collected and preserved using AcceGen's Saliva DNA Collection and Preservation Devices, as well as fresh saliva samples.Saliva DNA purified using AcceGen's kit is of the excellent quality, and is compatible with a number of downstream research applications including PCR, qPCR, Southern Blot analysis, sequencing and microarray analysis.

Saliva DNA Isolation Kit

K5011050 1 kit
EUR 261

Genomic DNA Isolation Kit

55R-1362 50 assays
EUR 273
  • Assay Kit containing the folllowing: Cell Lysis Buffer, Enzyme Mix (lyophilized), TE Buffer
Description: Genomic DNA Isolation Kit for use in the research laboratory

Genomic DNA Isolation Kit

GWB-AXR187 50 assays Ask for price

Genomic DNA Isolation Kit

K2118-50 50 assays
EUR 389
Description: Isolates highly pure Genomic DNA within 90 min.

Genomic DNA Isolation Kit

K281-50 each
EUR 326.4

Genomic DNA Isolation Kit

abx460025-1096tests 10 × 96 tests Ask for price

Genomic DNA Isolation Kit

abx460025-596tests 5 × 96 tests Ask for price

Genomic DNA Isolation Kit

abx460025-96tests 96 tests
EUR 437.5

FitAmp Gel DNA Isolation Kit

P-1007 100 Samples
EUR 324.48

Plant/Fungi DNA Isolation Kit

10760114-1 50 Prep(s)
EUR 350.39

Whole Blood DNA Isolation Kit

K528-100 each
EUR 451.2

FitAmp Urine DNA Isolation Kit 

P-1017
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 Samples
  • 50 Samples
  • 100 Samples

XCF Exosomal DNA Isolation Kit

XCF200A-1 20 rxn
EUR 328

FastPure FFPE DNA Isolation Kit

DC105-01 50 rxns
EUR 75.2

Genomic DNA Isolation Kit (Plant)

PDC10-0100 100 rxns
EUR 132

Viral DNA/RNA Isolation Kit

AGDK-0044 Kit Ask for price
Description: The Viral DNA/RNA Isolation Kit is intended for rapid co-extraction of viral DNA and RNA from a variety of biofluid samples, such as, plasma, serum, milk and swap samples. The proprietary microspherical paramagnetic beads used in the kit have a large binding surfaces and a high affinity towards nucleic acids. Going through sample lysis/binding, washing, and elution steps, the whole process can be completed under 35 minutes, and yields highly pure nucleic acids elute.  The recovered nucleic acids can be used in a wide range of applications, such as PCR, RT-PCR, Sanger Sequencing, NGS, and gene chips.

Genoirse Plant DNA Isolation Kit

GR101083 50
EUR 223

Genomic DNA Isolation Kit (Tissue)

PDC11-0100 100 rxns
EUR 132

Bacterial Genomic DNA Isolation Kit

K309-100 each
EUR 451.2

Blood and Serum DNA Isolation Kit

K5017100 1 kit
EUR 391

Genomic DNA isolation dual kit

PDC02-0100 100 rxns
EUR 110

HipurA® Cotton DNA Isolation Kit

MB528-250PR 1 unit
EUR 213.83
Description: HipurA® Cotton DNA Isolation Kit

HipurA® Cotton DNA Isolation Kit

MB528-50PR 1 unit
EUR 47.85
Description: HipurA® Cotton DNA Isolation Kit

HiPurA® Banana DNA Isolation Kit

MB533-250PR 1 unit
EUR 182.59
Description: HiPurA® Banana DNA Isolation Kit

HiPurA® Banana DNA Isolation Kit

MB533-50PR 1 unit
EUR 46.63
Description: HiPurA® Banana DNA Isolation Kit

Geneaid™ DNA Isolation Kit (Blood)

GEB003 each
EUR 3

Geneaid™ DNA Isolation Kit (Blood)

GEB01K each
EUR 450

Geneaid™ DNA Isolation Kit (Blood)

GEB100 each
EUR 75

Geneaid™ DNA Isolation Kit (Yeast)

GEY004 each
EUR 3

Geneaid™ DNA Isolation Kit (Yeast)

GEY100 each
EUR 64.5

Geneaid™ DNA Isolation Kit (Yeast)

GEY300 each
EUR 174

Apoptotic DNA Ladder Isolation Kit

GWB-AXR127 50 assays Ask for price

Apoptotic DNA Ladder Isolation Kit

K170-50 each
EUR 561.6

Apoptotic DNA Ladder Isolation Kit

K2045-50 50 assays
EUR 490
Description: No genomic DNA contamination.

Geneaid™ DNA Isolation Kit (Tissue)

GET005 each
EUR 3

Geneaid™ DNA Isolation Kit (Tissue)

GET1.5K each
EUR 550

Geneaid™ DNA Isolation Kit (Tissue)

GET150 each
EUR 92.5

Dual Genomic DNA Isolation Kit (Plant)

PDC05-0100 100 rxns
EUR 154

FitAmp Plasma/Serum DNA Isolation Kit 

P-1004
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 Samples
  • 50 Samples
  • 100 Samples

Geneaid™ DNA Isolation Kit (Bacteria)

GEE005 each
EUR 3

Geneaid™ DNA Isolation Kit (Bacteria)

GEE1.5K each
EUR 450

Geneaid™ DNA Isolation Kit (Bacteria)

GEE150 each
EUR 75

Dual Genomic DNA Isolation Kit(Tissue)

PDC06-0100 100 rxns
EUR 154

Genomic DNA Isolation Reagent Kit

abx460021-1096tests 10 × 96 tests Ask for price

Genomic DNA Isolation Reagent Kit

abx460021-596tests 5 × 96 tests Ask for price

Genomic DNA Isolation Reagent Kit

abx460021-96tests 96 tests
EUR 325

Rapid Fungal Genomic DNA Isolation Kit

FT71415 50Preps
EUR 91.97
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Fungi

Plant Tissue Genomic DNA Isolation Kit

K316-100 each
EUR 451.2

Easy3-Plant Genomic DNA Isolation Kit

FYG503-100P 100 Preps Ask for price

Easy3-Plant Genomic DNA Isolation Kit

FYG503-500P 500 Preps Ask for price

Rapid Bacteria Genomic DNA Isolation Kit

BS8225 50Preps
EUR 91.97
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Bacteria

Mammalian Cell Genomic DNA Isolation Kit

K967-100 each
EUR 457.2

HiPurA® SPP Blood DNA Isolation Kit

MB541-10ML 1 unit
EUR 27.19
Description: HiPurA® SPP Blood DNA Isolation Kit

HiPurA® SPP Blood DNA Isolation Kit

MB541-150ML 1 unit
EUR 155.06
Description: HiPurA® SPP Blood DNA Isolation Kit

HiPurA® SPP Blood DNA Isolation Kit

MB541-300ML 1 unit
EUR 242.51
Description: HiPurA® SPP Blood DNA Isolation Kit

HiPurA® SPP Blood DNA Isolation Kit

MB541-50ML 1 unit
EUR 68.71
Description: HiPurA® SPP Blood DNA Isolation Kit

Soil DNA Isolation Mini Kit (100prep)

FASOI-001-1 100 preps
EUR 241.2

Soil DNA Isolation Mini Kit (100prep)

FASOI_001-1 1 kit
EUR 90

Soil DNA Isolation Mini Kit (50prep)

FASOI-001 50 preps
EUR 189.6

Soil DNA Isolation Midi Kit (24prep)

FASOI-002 24 preps
EUR 259.2

Soil DNA Isolation Mini Kit (50prep)

FASOI_001 1 kit
EUR 45

Geneaid™ DNA Isolation Kit (Blood) Plus

GEB01K-A each
EUR 480

Geneaid™ DNA Isolation Kit (Tissue) Plus

GET1.5K-A each
EUR 594

FastPure FFPE DNA Isolation Mini Kit

DC105 50 rxn
EUR 241.2

Geneaid™ DNA Isolation Kit (Cultured Cell)

GEC005 each
EUR 3

Geneaid™ DNA Isolation Kit (Cultured Cell)

GEC1.5K each
EUR 360

Geneaid™ DNA Isolation Kit (Cultured Cell)

GEC150 each
EUR 60

Geneaid™ DNA Isolation Kit (Bacteria) Plus

GEE1.5K-A each
EUR 480

FastPure Plant DNA Isolation Mini Kit

DC104 50 rxn
EUR 192

FastPure Plant DNA Isolation Mini Kit

DC104-01 50 rxns
EUR 60

Genomic DNA Isolation Reagent

PDR01-0100 100 rxns
EUR 88

HiPurA® Plant DNA Isolation Kit (CTAB Me

MB502-50PR 1 unit
EUR 33.57
Description: HiPurA® Plant DNA Isolation Kit (CTAB Me

Plant Genomic DNA Isolation Reagent Kit

abx460022-1096tests 10 × 96 tests Ask for price

Plant Genomic DNA Isolation Reagent Kit

abx460022-596tests 5 × 96 tests Ask for price

Plant Genomic DNA Isolation Reagent Kit

abx460022-96tests 96 tests
EUR 325

One-Tube Bacteria Genomic DNA Isolation Kit

BS8413 100preps
EUR 94.72
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Bacteria

One-Tube Bacteria Genomic DNA Isolation Kit

BS8414 500Preps, 500prep
EUR 198.85
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Bacteria

FastPure Bacteria DNA Isolation Mini Kit

DC103 100 rxn
EUR 212.4

FastPure Bacteria DNA Isolation Mini Kit

DC103-01 100 rxns
EUR 52

Column-Pure Animal Genomic DNA Isolation Kit

D512 50 Preparations
EUR 195

FitAmp General Tissue Section DNA Isolation Kit 

P-1003
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 Samples
  • 50 Samples
  • 100 Samples

HipurA® Silica Kit for DNA Isolation

MB503-400PR 1 unit
EUR 47.85
Description: HipurA® Silica Kit for DNA Isolation

FitAmp Paraffin Tissue Section DNA Isolation Kit 

P-1009
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 Samples
  • 50 Samples
  • 100 Samples

Column-Pure Bacterial Genomic DNA Isolation Kit

D511 50 Preparations
EUR 195

EpiQuik Circulating Cell-Free DNA Isolation Kit

P-1064
  • Ask for price
  • Ask for price
  • Ask for price
  • 50 Isolations
  • 25 Isolations
  • 50 Isolations

FastPure Blood DNA Isolation Mini Kit V2

DC111-01 50 rxn
EUR 214.8

FastPure Blood DNA Isolation Mini Kit V2

DC111-02 200 rxn
EUR 472.8

Geneaid™ DNA Isolation Kit (Cultured Cell) Plus

GEC1.5K-A each
EUR 400

Genomic DNA Isolation Kit (Paraffin-embedded tissue)

PDC12-0100 100 rxns
EUR 132

Soil DNA Plus Isolation Mini Kit (100prep)

FAPSO-001-1 100 preps
EUR 241.2

FastPure Cell/Tissue DNA Isolation Mini Kit

DC102 100 rxn
EUR 212.4

FastPure Cell/Tissue DNA Isolation Mini Kit

DC102-01 100 rxns
EUR 52

Plasmid DNA Isolation Solution I

10760028-1 250 mL
EUR 29.83

Plasmid DNA Isolation Solution I

10760028-2 500 mL
EUR 45.3

Plasmid DNA Isolation Solution II

10760029-1 250 mL
EUR 29.83

Plasmid DNA Isolation Solution II

10760029-2 500 mL
EUR 37.89

Soil DNA Plus Isolation Mini Kit (50prep)

FAPSO-001 50 preps
EUR 189.6

Methylamp Coupled DNA Isolation & Modification Kit

P-1002 40 Samples
EUR 474.12

Plasmid DNA Isolation Solution III

10760030-1 250 mL
EUR 28.07

Plasmid DNA Isolation Solution III

10760030-2 500 mL
EUR 43

Genomic DNA Isolation Kit (Blood/Cultured Cell/Fungus)

PDC09-0100 100 rxns
EUR 99

Plant Genomic DNA Isolation Reagent

PDR02-0100 100 rxns
EUR 88

QC Buffer for Plasmid DNA Isolation

10760036-1 250 mL
EUR 25.45

QC Buffer for Plasmid DNA Isolation

10760036-2 500 mL
EUR 43.01

QF Buffer for Plasmid DNA Isolation

10760037-1 250 mL
EUR 24.44

QF Buffer for Plasmid DNA Isolation

10760037-2 500 mL
EUR 43.01

QF Buffer for Plasmid DNA Isolation

10760037-3 1 L
EUR 76.87

One Tube Viral DNA Isolation Buffer

VT4785 50Preps
EUR 224.44
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Viral

One Tube Viral DNA Isolation Buffer

VT4786 100preps
EUR 388.86
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Viral

Magnetic Cell-Free DNA Isolation Kit, 50 reactions/pk

208301 6 pcs/cs
EUR 183.37
Description: Magnetic Cell-Free DNA Isolation Kit, 50 reactions/pk

EpiMag High Throughput DNA Isolation Universal Kit

P-1022-96 96 Samples
EUR 227.7

EpiMag High Throughput DNA Isolation Universal Kit

P-1022 96 Samples
EUR 215

QBT Buffer for Plasmid DNA Isolation

10760035-1 250 mL
EUR 34.22

QBT Buffer for Plasmid DNA Isolation

10760035-2 500 mL
EUR 49.13

QBT Buffer for Plasmid DNA Isolation

10760035-3 1 L
EUR 71.93

Hipro Circulating Cell-Free DNA (cfDNA) Isolation Kit

W2603-10 10 rxn
EUR 319

Hipro Circulating Cell-Free DNA (cfDNA) Isolation Kit

W2603-20 20 rxn
EUR 499

Hipro Circulating Cell-Free DNA (cfDNA) Isolation Kit

W2603-50 NULL Ask for price

We clonal track thousands of cancer cells, connecting epigenomic variability subclonal evolution and infer cellular dynamics differentiating hematopoietic cells in vitro and in vivo. Taken together, our approach allows the study of population dynamics of cellular and in vivo clonal nature.