The association between mitochondrial DNA copy number, telomere length, and tubal pregnancy

Growing evidence has shown a link between the occurrence of ectopic tubal pregnancy (TP) and the status of oxidative stress (OS), in which the mitochondria and telomeres play an important role. However, little is known about the underlying correlation between TP and the number of copies of mitochondrial DNA (mtDNAcn) or telomere length (TL) abnormalities. In this study, we found the OS level increased in patients with TP.

We hierarchical detect relative mtDNAcn and NE of the villi of normal pregnancy (NP) and TP samples according to different gestational age, fetal sex, maternal age, and BMI. The results showed that the relative mtDNAcn significantly lowered in the villi in the TP group compared with the NP group, which is negatively correlated with the status of the OS. In the NP group, which mtDNAcn the subgroup of women was apparently lower than in the subgroup of men, while there was no statistical difference was found in mtDNAcn in TP group between subgroups of women and men. Additionally, TL relative in TP group were on the same level with the NP group, and there was no statistical correlation was observed between the relative NE and OS level. In summary, our findings suggest that abnormal levels mtDNAcn than TL correlated with TP, which provides new insight into the mechanism of the TP.


local chicken population is a major source of food in rural areas of Algeria. However, as long as they have not been marked. The purpose of this study was to assess the genetic diversity and origin mother domestic chicken of five areas of agro-ecological Algeria West: beach (CT), terrain inland (IP), plateau (HL), mountain (MT) and sahara (SH, including Oasis, Req and Erg region). A set of 88 mitochondrial DNA (mtDNA) D-loop sequences including me hypervariable regions (HV1) were analyzed. Of 397 bp D-loop sequences, 20 variable sites defined 13 haplotypes were identified in the Algerian domestic chicken. Haplotype and nucleotide diversity was estimated as 0.597 and 0.003, respectively.

Phylogenetic and tissue analysis showed two clades or haplogroups (A and E). Only one clade A haplotypes were observed exclusively in the mountains of the population, while, Clade E haplotype is found in almost all chicken Algeria with twelve different haplotypes. These findings show that Algeria chicken came from haplogroup most everywhere that has its roots in the Indian subcontinent. Our results provide important information about the origin of chicken North-West Africa and a historical spread of the first chicken population to the African continent.

 The association between mitochondrial DNA copy number, telomere length, and tubal pregnancy
The association between mitochondrial DNA copy number, telomere length, and tubal pregnancy

Massively parallel single-cell genotypes of mitochondrial DNA and chromatin profile

Natural mitochondrial DNA (mtDNA) mutations allow the inference clonal relationships between cells. mtDNA can be profiled along with measures cell state, but has not been coupled with massively parallel approach is needed to address the complexity of human tissue.

Here, we introduce a high-throughput, mitochondria droplet-based single-cell assay for chromatin transposase accessed by sequencing (scATAC-seq), a method that combines high confidence mtDNA mutation called thousands of single cells with their simultaneous high quality accessible chromatin profile. This allows the inference mtDNA heteroplasmi, clonal relationship, the state of cells and accessible chromatin variation in individual cells. We reveal the single-cell variation in mtDNA heteroplasmi of pathological variants, which we associate with chromatin intra-individual variability and clonal evolution.

Mitochondrial DNA Isolation Kit

K280-50
EUR 588.00

Genomic DNA Isolation Kit

55R-1362 50 assays
EUR 385.00
Description: Genomic DNA Isolation Kit for use in the research laboratory

Genomic DNA Isolation Kit

K2118-50 50 assays
EUR 321.00

Saliva DNA Isolation Kit

K5011050 1 kit
EUR 256.00

Urine DNA Isolation Kit

K5011150 1 kit
EUR 256.00

Stool DNA Isolation Kit

K5011250 1 kit
EUR 256.00

Serum DNA Isolation Kit

K5018100 1 kit
EUR 360.00

Genomic DNA Isolation Kit

K281-50
EUR 272.00

FitAmp Gel DNA Isolation Kit

P-1007 100 Samples
EUR 270.40
Description: The best epigenetics products

FitAmp Urine DNA Isolation Kit

P-1017 100 Samples
EUR 395.10
Description: kits suitable for this type of research

Apoptotic DNA Ladder Isolation Kit

K2045-50 50 assays
EUR 502.00

Apoptotic DNA Ladder Isolation Kit

K170-50
EUR 468.00

Whole Blood DNA Isolation Kit

K528-100
EUR 376.00

Bacterial Genomic DNA Isolation Kit

K309-100
EUR 376.00

XCF Exosomal DNA Isolation Kit

XCF200A-1 20 rxn
EUR 386.00
  • Category: Exosome

100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP 1/pk
EUR 73.00
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT

M-DNA-1KB 1/pk
EUR 70.00
Description: Bioscience Mol Bio; DNA Ladder

FastPure Bacteria DNA Isolation Mini Kit

DC103 100 rxn
EUR 177.00

FastPure Plant DNA Isolation Mini Kit

DC104 50 rxn
EUR 160.00

FastPure FFPE DNA Isolation Mini Kit

DC105 50 rxn
EUR 201.00

Rapid Bacteria Genomic DNA Isolation Kit

BS8225 50Preps
EUR 76.64
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Bacteria

Methylamp Coupled DNA Isolation & Modification Kit

P-1002 40 Samples
EUR 395.10
Description: The best epigenetics products

FitAmp Plasma/Serum DNA Isolation Kit

P-1004 100 Samples
EUR 347.25
Description: fast delivery possible

Rapid Fungal Genomic DNA Isolation Kit

FT71415 50Preps
EUR 76.64
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Fungi

Easy3-Plant Genomic DNA Isolation Kit

FYG503-100P 100 Preps Ask for price

Easy3-Plant Genomic DNA Isolation Kit

FYG503-500P 500 Preps Ask for price

Soil DNA Isolation Mini Kit (50prep)

FASOI-001 50 preps
EUR 158.00

Soil DNA Isolation Mini Kit (100prep)

FASOI-001-1 100 preps
EUR 201.00

Soil DNA Isolation Midi Kit (24prep)

FASOI-002 24 preps
EUR 216.00

Mammalian Cell Genomic DNA Isolation Kit

K967-100
EUR 381.00

Blood and Serum DNA Isolation Kit

K5017100 1 kit
EUR 360.00

Plant Tissue Genomic DNA Isolation Kit

K316-100
EUR 376.00

FastPure Cell/Tissue DNA Isolation Mini Kit

DC102 100 rxn
EUR 177.00

FastPure Blood DNA Isolation Mini Kit V2

DC111-01 50 rxn
EUR 179.00

FastPure Blood DNA Isolation Mini Kit V2

DC111-02 200 rxn
EUR 394.00

One-Tube Bacteria Genomic DNA Isolation Kit

BS8413 100preps
EUR 78.93
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Bacteria

One-Tube Bacteria Genomic DNA Isolation Kit

BS8414 500Preps, 500prep
EUR 165.71
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Bacteria

FitAmp General Tissue Section DNA Isolation Kit

P-1003 100 Samples
EUR 628.55
Description: kits suitable for this type of research

FitAmp Paraffin Tissue Section DNA Isolation Kit

P-1009 100 Samples
EUR 585.05
Description: Ask the seller for details

EpiQuik Circulating Cell-Free DNA Isolation Kit

P-1064 50 Isolations
EUR 347.25
Description: kits suitable for this type of research

Soil DNA Plus Isolation Mini Kit (50prep)

FAPSO-001 50 preps
EUR 158.00

Soil DNA Plus Isolation Mini Kit (100prep)

FAPSO-001-1 100 preps
EUR 201.00

One Tube Viral DNA Isolation Buffer

VT4785 50Preps
EUR 187.03
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Viral

One Tube Viral DNA Isolation Buffer

VT4786 100preps
EUR 324.05
  • Product category: Molecular Biology Kits/DNA - Extraction (Genomic)/Viral

Hipro Circulating Cell-Free DNA (cfDNA) Isolation Kit

W2603-10 NULL
EUR NULL

Hipro Circulating Cell-Free DNA (cfDNA) Isolation Kit

W2603-20 NULL
EUR NULL

Hipro Circulating Cell-Free DNA (cfDNA) Isolation Kit

W2603-50 NULL
EUR NULL

Mitochondrial DNA Purification Kit

K389-25
EUR 392.00

EpiQuik Circulating Cell-Free DNA (ccfDNA) Isolation Easy Kit

P-1065 50 Isolations
EUR 347.25
Description: fast delivery possible

Mitochondria Isolation Kit

AR0156 1 kit
EUR 106.00

miRNA Isolation Kit

FYG304-100P 100 Preps Ask for price

miRNA Isolation Kit

FAMIK--001 Rxns: 100
EUR 332.00
Description: Contents of the kit:
  • Rxns:100Lysis
  • Buffer-10 ml
  • Acid-Phenol-10 ml
  • RNA Column and Collection Tube-100 sets
  • Wash Buffer-10 ml
  • Release Buffer-0.5 ml

miRNA Isolation Kit

FAMIK--002 Rxns: 50
EUR 223.00

MicroRNA Isolation Kit

KS341025 1 kit
EUR 256.00
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Endosome Isolation Kit

P528 NULL
EUR NULL

Preadipocyte Isolation Kit

K583-5
EUR 533.00

Microsome Isolation Kit

K249-50
EUR 528.00

Stool DNA Isolation Mini Kit (50prep), with Proteinase K Powder

FASTI001 50 preps
EUR 165.00

Stool DNA Isolation Mini Kit (100prep), with Proteinase K Powder

FASTI001-1 100 preps
EUR 218.00

Human Mitochondrial DNA Copy Number Kit

MCN1 1 Kit
EUR 349.00

Rat Mitochondrial DNA Copy Number Kit

MCN2 1 Kit
EUR 349.00

Mouse Mitochondrial DNA Copy Number Kit

MCN3 1 Kit
EUR 349.00

Apoptotic Cell Isolation Kit

55R-1349 30 units
EUR 729.00
Description: Apoptotic Cell Isolation Kit for use in the research laboratory

Cell Mitochondria Isolation Kit

abx090630-50100tests 50-100 tests
EUR 258.00
  • Shipped within 5-10 working days.

Tissue Mitochondria Isolation Kit

abx090631-50100assays 50-100 assays
EUR 258.00
  • Shipped within 5-10 working days.

Total RNA Isolation Kit

P-9100 50 samples
EUR 347.25
Description: The best epigenetics products

Easy3-RNA Isolation Kit

FYG501-100P 100 Preps Ask for price

Easy3-RNA Isolation Kit

FYG501-500P 500 Preps Ask for price

Cartilage RNA Isolation Kit

K2031010 1 kit
EUR 419.00
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

ExoPure? Isolation Kit   (Urine)

K1240-10
EUR 697.00

ExoPure? Isolation Kit   (Urine)

K1240-2
EUR 403.00

Lipid Droplet Isolation Kit

MET-5011 50 preps
EUR 415.00
Description: Lipid droplets are lipid rich organelles found in the adipose tissue of eukaryotes. They function to regulate the hydrolysis and storage of neutral lipids and serve as storage for cholesterol and acyl-glycerols. Lipid droplets have also been associated with inflammatory responses, obesity, atherosclerosis, and cancer.

Lipopolysaccharide (LPS) Isolation Kit

K438-10
EUR 278.00

Yeast Nuclei Isolation Kit

K289-50
EUR 392.00

Apoptotic Cell Isolation Kit

K258-30
EUR 468.00

Yeast Mitochondria Isolation Kit

K259-50
EUR 419.00

FavorPrep Stool DNA Plus Isolation Mini Kit (50prep), with Proteinase K Powder

FAPST001 50 preps
EUR 165.00

FavorPrep Stool DNA Plus Isolation Mini Kit (100prep), with Proteinase K Powder

FAPST001-1 100 preps
EUR 218.00

Frit Kit

FRIT-KIT 1each
EUR 124.00
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

Column Packing Kit

PACK-KIT 1pack
EUR 1035.00
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

PCR Mycoplasma Detection Kit

M034-Kit Kit
EUR 266.00

Rapid Bacteria RNA Isolation Kit

BS8625 50Preps
EUR 79.69
  • Product category: Molecular Biology Kits/RNA - Extraction/Bacteria

Rapid Blood RNA Isolation Kit

BT4182 10Preps
EUR 81.97
  • Product category: Molecular Biology Kits/RNA - Extraction/Blood

Rapid Blood RNA Isolation Kit

BT4183 50Preps
EUR 164.19
  • Product category: Molecular Biology Kits/RNA - Extraction/Blood

Rapid Blood RNA Isolation Kit

BT4184 250preps
EUR 506.75
  • Product category: Molecular Biology Kits/RNA - Extraction/Blood

ChromaFlash Chromatin Isolation & Shearing Kit

P-2023 100 Preperations
EUR 270.40
Description: kits suitable for this type of research

Total RNA Isolation Kit (Tissue)

P-9102 50 samples
EUR 347.25
Description: reagents widely cited

Total RNA Isolation Kit (Plant)

P-9104 50 samples
EUR 347.25
Description: kits suitable for this type of research

Rapid Plant RNA Isolation Kit

PT4191 50Preps
EUR 79.69
  • Product category: Molecular Biology Kits/RNA - Extraction/Plant

Easy3-Plant RNA Isolation Kit

FYG502-100P 100 Preps Ask for price

Easy3-Plant RNA Isolation Kit

FYG502-500P 500 Preps Ask for price

Easy3-Total NucleicAcid Isolation Kit

FYG504-100ML 100 ml Ask for price

Easy3-Total NucleicAcid Isolation Kit

FYG504-500ML 500 ml Ask for price

Exo-Urine EV Isolation Kit

EXOU100A-1 2 x 5 reactions
EUR 551.00

Circulating Nuleic Acid Isolation Kit

FACFK-050 50 preps
EUR 491.00

Circulating Nuleic Acid Isolation Kit

FACFK-100 100 preps
EUR 825.00

Total RNA Isolation Kit II

FATRS--001 100 preps
EUR 308.00

Total RNA Isolation Kit II

FATRS--050 50 preps
EUR 216.00

ExoPure? Isolation Kit   (Cell Media)

K1237-10
EUR 664.00

ExoPure? Isolation Kit   (Cell Media)

K1237-2
EUR 392.00

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-10
EUR 697.00

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-2
EUR 392.00

ExoPure? Isolation Kit   (Bio Fluids)

K1241-10
EUR 697.00

ExoPure? Isolation Kit   (Bio Fluids)

K1241-2
EUR 403.00

Detergent-Free Nuclei Isolation Kit

P524-2 NULL
EUR NULL

Detergent-Free Nuclei Isolation Kit

P524-20 NULL
EUR NULL

Detergent-Free Nuclei Isolation Kit

P524-80 NULL
EUR NULL

Lysosome Isolation Kit (20 tests)

P534 NULL
EUR NULL

Mouse Brain Microvessel Isolation Kit

P750-4 NULL
EUR NULL

Exosome Isolation kit (for urine)

P120L NULL
EUR NULL

Exosome Isolation kit (for urine)

P120S NULL
EUR NULL

Org Frontier? Chloroplast Isolation Kit

K468-10
EUR 555.00

OrgFrontier? Plasma Membrane Isolation Kit

K414-10
EUR 566.00

Cell Surface Protein Isolation Kit

K295-10
EUR 501.00

EZExtract? Core Histone Isolation Kit

K234-100
EUR 262.00

PSEUDOMONAS ISOLATION AGAR

P16-114-10kg 10 kg
EUR 1715.00

PSEUDOMONAS ISOLATION AGAR

P16-114-2kg 2kg
EUR 412.00

PSEUDOMONAS ISOLATION AGAR

P16-114-500g 500 g
EUR 148.00

PSEUDOMONAS ISOLATION BROTH

P16-115-10kg 10 kg Ask for price

PSEUDOMONAS ISOLATION BROTH

P16-115-2Kg 2 Kg Ask for price

PSEUDOMONAS ISOLATION BROTH

P16-115-500g 500 g Ask for price

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1110.00
  • Category: Cas9

Human DNA topoisomerase I, mitochondrial (TOP1MT) ELISA Kit

abx383869-96tests 96 tests
EUR 911.00
  • Shipped within 5-12 working days.

Mouse DNA topoisomerase I, mitochondrial, Top1mt ELISA KIT

ELI-17143m 96 Tests
EUR 865.00

Human DNA topoisomerase I, mitochondrial, TOP1MT ELISA KIT

ELI-36475h 96 Tests
EUR 824.00

CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV100PA-KIT 1 Kit
EUR 1132.00
  • Category: Cas9

CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV105PA-KIT 1 Kit
EUR 1132.00
  • Category: Cas9

MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV120PA-KIT 1 Kit
EUR 1132.00
  • Category: Cas9

MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV125PA-KIT 1 Kit
EUR 1132.00
  • Category: Cas9

DNA Topoisomerase I, Mitochondrial (TOP1MT) Antibody

abx238866-100ug 100 ug
EUR 551.00
  • Shipped within 5-12 working days.

Recombinant human DNA topoisomerase I, mitochondrial

P2243 100ug Ask for price
  • Uniprot ID: Q969P6
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human DNA topoisomerase I, mitochondrial

Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS700A-KIT 10 rxn
EUR 1132.00
  • Category: Cas9

Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS720A-KIT 10 rxn
EUR 1132.00
  • Category: Cas9

Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS740A-KIT 10 rxn
EUR 1132.00
  • Category: Cas9

T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)

CAS510A-KIT 1 Kit
EUR 805.00
  • Category: Cas9

Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV200PA-KIT 1 Kit
EUR 1132.00
  • Category: Cas9

Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV205PA-KIT 1 Kit
EUR 1132.00
  • Category: Cas9

Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV220PA-KIT 1 Kit
EUR 1132.00
  • Category: Cas9

Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV225PA-KIT 1 Kit
EUR 1132.00
  • Category: Cas9

Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS750A-KIT 10 rxn
EUR 1132.00
  • Category: Cas9

Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS770A-KIT 10 rxn
EUR 1132.00
  • Category: Cas9

Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS790A-KIT 10 rxn
EUR 1132.00
  • Category: Cas9

Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)]

CAS9LIG-KIT 1 Kit
EUR 153.00
  • Category: Cas9

Mammalian Mitochondria Isolation Kit for Tissue

abx098857-50rxns 50 rxns
EUR 411.00
  • Shipped within 5-10 working days.

Exosome Isolation kit (for serum & plasma)

P101 NULL
EUR NULL

Exosome Isolation kit (for serum & plasma)

P101L NULL
EUR NULL

Exosome Isolation kit (for serum & plasma)

P101S NULL
EUR NULL

Soil RNA Isolation Mini Kit (50prep)

FASRK-001 50 preps
EUR 150.00

Soil RNA Isolation Mini Kit (100prep)

FASRK-100 100 preps
EUR 187.00

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-10
EUR 751.00

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-2
EUR 425.00

Broad Range Total RNA Isolation Kit

K1341050 1 kit
EUR 266.00
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Human Whole Blood Monocyte Isolation Kit

K933-30
EUR 376.00

Mitochondria Isolation Kit (Mammalian cells / tissues)

P507L NULL
EUR NULL

10-min. Single Cell Isolation Kit

P713-20 NULL
EUR NULL

We clonal track thousands of cancer cells, connecting epigenomic variability subclonal evolution and infer cellular dynamics differentiating hematopoietic cells in vitro and in vivo. Taken together, our approach allows the study of population dynamics of cellular and in vivo clonal nature.