Description: True Blue

Description: True Blue

Description: True Blue

Description: True Blue

Description: JBS True Blue

Description: Pharmalogical properties virtually identical to native dopamine. DnsylD-1 operates selectively in uptake and binding assays at nanomolar concentrations.  The native dopamine chemical structure is the major component of this fluorescent catecholamine, generating a fluorescent neurotransmitter molecule with high affinity toward all dopamine receptor subtypes as well as to the dopamine transporter. The small dansyl tag with a 5-carbon polylinker to dopamine generates a stable, bright fluorescent signal with negligible steric hindrance. The dansyl fluorescent tag offers a large stokes shift that minimizes autofluorescence and non-specific background signals:  (Ex/Em:  313/515nm). The fluorescent signal of DnsylD-1TM is blockable by standard inhibitors to dopamine receptors and DAT. Standard inhibitors can be employed to distinguish the interaction of DnsylD-1TM with dopamine receptors and DAT. Fluorescence from DnsylD-1TM colocalizes with tyrosine hydroxylase and identifies dopaminergic neurons. To assay for dopamine receptor binding, first suspend the provided solid in DMSO (10 - 50 µl).  Centrifuge to clarify, and collect the DMSO soluble fraction, which can be aliquoted and stored at -20oC:  DnsylD-1TM when suspended in DMSO and frozen at -20oC is stable for at least 2 years.  Dilute the DMSO solubilized material into your assay buffer (for example PBS-BSA) to the desired assay concentration.  Detect DnsylD-1TM by fluorescent microscopy, with a fluorescent

Description: Pharmalogical properties virtually identical to native dopamine. DnsylD-1 operates selectively in uptake and binding assays at nanomolar concentrations.  The native dopamine chemical structure is the major component of this fluorescent catecholamine, generating a fluorescent neurotransmitter molecule with high affinity toward all dopamine receptor subtypes as well as to the dopamine transporter. The small dansyl tag with a 5-carbon polylinker to dopamine generates a stable, bright fluorescent signal with negligible steric hindrance. The dansyl fluorescent tag offers a large stokes shift that minimizes autofluorescence and non-specific background signals:  (Ex/Em:  313/515nm). The fluorescent signal of DnsylD-1TM is blockable by standard inhibitors to dopamine receptors and DAT. Standard inhibitors can be employed to distinguish the interaction of DnsylD-1TM with dopamine receptors and DAT. Fluorescence from DnsylD-1TM colocalizes with tyrosine hydroxylase and identifies dopaminergic neurons. To assay for dopamine receptor binding, first suspend the provided solid in DMSO (10 - 50 µl).  Centrifuge to clarify, and collect the DMSO soluble fraction, which can be aliquoted and stored at -20oC:  DnsylD-1TM when suspended in DMSO and frozen at -20oC is stable for at least 2 years.  Dilute the DMSO solubilized material into your assay buffer (for example PBS-BSA) to the desired assay concentration.  Detect DnsylD-1TM by fluorescent microscopy, with a fluorescent

Description: Pharmalogical properties virtually identical to native dopamine. DnsylD-1 operates selectively in uptake and binding assays at nanomolar concentrations.  The native dopamine chemical structure is the major component of this fluorescent catecholamine, generating a fluorescent neurotransmitter molecule with high affinity toward all dopamine receptor subtypes as well as to the dopamine transporter. The small dansyl tag with a 5-carbon polylinker to dopamine generates a stable, bright fluorescent signal with negligible steric hindrance. The dansyl fluorescent tag offers a large stokes shift that minimizes autofluorescence and non-specific background signals:  (Ex/Em:  313/515nm). The fluorescent signal of DnsylD-1TM is blockable by standard inhibitors to dopamine receptors and DAT. Standard inhibitors can be employed to distinguish the interaction of DnsylD-1TM with dopamine receptors and DAT. Fluorescence from DnsylD-1TM colocalizes with tyrosine hydroxylase and identifies dopaminergic neurons. To assay for dopamine receptor binding, first suspend the provided solid in DMSO (10 - 50 µl).  Centrifuge to clarify, and collect the DMSO soluble fraction, which can be aliquoted and stored at -20oC:  DnsylD-1TM when suspended in DMSO and frozen at -20oC is stable for at least 2 years.  Dilute the DMSO solubilized material into your assay buffer (for example PBS-BSA) to the desired assay concentration.  Detect DnsylD-1TM by fluorescent microscopy, with a fluorescent

Description: 3’-Ferrocene CPG is a reagent used in oligonucleotide synthesis.   Ferrocene CPG is used to attach a Ferrocene molecule at the 3’-end of oligonucleotides.  A Ferrocene linked oligonucleotide provides high sensitivity detection with electrochemical techniques such as impedance analysis.  Specifications:  Chemical Name:  1-Dimethoxytrityloxy-3-N-carboxy-Ferrocene- propyl-2-O-succinoyl-long chain alkylamino-CPG. Purity:  >98% purity Appearance:  Light yellow solid Storage:  4oC, desiccate.  Ships at ambient temperature

Description: 3’-Ferrocene CPG is a reagent used in oligonucleotide synthesis.   Ferrocene CPG is used to attach a Ferrocene molecule at the 3’-end of oligonucleotides.  A Ferrocene linked oligonucleotide provides high sensitivity detection with electrochemical techniques such as impedance analysis.  Specifications:  Chemical Name:  1-Dimethoxytrityloxy-3-N-carboxy-Ferrocene- propyl-2-O-succinoyl-long chain alkylamino-CPG. Purity:  >98% purity Appearance:  Light yellow solid Storage:  4oC, desiccate.  Ships at ambient temperature

Description: 3’-Ferrocene CPG is a reagent used in oligonucleotide synthesis.   Ferrocene CPG is used to attach a Ferrocene molecule at the 3’-end of oligonucleotides.  A Ferrocene linked oligonucleotide provides high sensitivity detection with electrochemical techniques such as impedance analysis.  Specifications:  Chemical Name:  1-Dimethoxytrityloxy-3-N-carboxy-Ferrocene- propyl-2-O-succinoyl-long chain alkylamino-CPG. Purity:  >98% purity Appearance:  Light yellow solid Storage:  4oC, desiccate.  Ships at ambient temperature

Description: Highly reactive NHS ester modification reagent to primary amines generating high yields of ferrocene conjugates. Widely employed in commercial oligonucleotide synthesis due to its efficacy. Since typically conjugated to primary amines with poly-C extensions, steric hindrance is negligible. Efficiently conjugated to primary amines on peptides, proteins and modified oligonucleotides

Description: Highly reactive NHS ester modification reagent to primary amines generating high yields of ferrocene conjugates. Widely employed in commercial oligonucleotide synthesis due to its efficacy. Since typically conjugated to primary amines with poly-C extensions, steric hindrance is negligible. Efficiently conjugated to primary amines on peptides, proteins and modified oligonucleotides

Description: Highly reactive NHS ester modification reagent to primary amines generating high yields of ferrocene conjugates. Widely employed in commercial oligonucleotide synthesis due to its efficacy. Since typically conjugated to primary amines with poly-C extensions, steric hindrance is negligible. Efficiently conjugated to primary amines on peptides, proteins and modified oligonucleotides

Description: Highly reactive NHS ester modification reagent to primary amines generating high yields of ferrocene conjugates. Widely employed in commercial oligonucleotide synthesis due to its efficacy. Since typically conjugated to primary amines with poly-C extensions, steric hindrance is negligible. Efficiently conjugated to primary amines on peptides, proteins and modified oligonucleotides

Description: Highly reactive NHS ester modification reagent to primary amines generating high yields of ferrocene conjugates. Widely employed in commercial oligonucleotide synthesis due to its efficacy. Since typically conjugated to primary amines with poly-C extensions, steric hindrance is negligible. Efficiently conjugated to primary amines on peptides, proteins and modified oligonucleotides

Description: Highly reactive NHS ester modification reagent to primary amines generating high yields of ferrocene conjugates. Widely employed in commercial oligonucleotide synthesis due to its efficacy. Since typically conjugated to primary amines with poly-C extensions, steric hindrance is negligible. Efficiently conjugated to primary amines on peptides, proteins and modified oligonucleotides

Description: Labeling reagent that generates electrochemically active oligonucleotides.