Developmental data for several human mitochondrial DNA (mtDNA) long amplification targets

Long prospective targets to ~ 300 bp mtDNA length identified in mtDNA Cambridge reference sequence revision using Primer Express software (Applied Biosystems) with a modified standard analysis settings. Primary and hydrolysis probe sequences to be generated three (3) goals wondered Mitomap database [1] to avoid common single nucleotide polymorphisms (SNPs), which, if present in the sample, it can reduce the binding to the template and therefore lead to inefficient amplification. Primer and probe are identified by Primer Express, some synthesized slumped to reduce the presence of a particular SNP, which is used in Advanced Master Mix (Applied Biosystems) rapid reaction strengthened in 7500 Real Time PCR System using Real Time PCR Software HID v1. 2 (Applied Biosystems) to collect and analyze data qPCR. qPCR reaction conditions and analysis software settings are optimized and modified to produce amplification efficient and powerful results.

QPCR experiments exported to Excel (Microsoft Corp.) for analysis and additional evaluation. The data used to develop the triplex qPCR methods, which include the amplification of the target long one, to measure and assess the degradation of human mtDNA, previously published results [2]. Triplex method that also included an internal positive control to test for the presence of amplification inhibitors in the sample [3]. The data presented here can be used to develop alternative amplification methods for biomedical applications specific users.


Autophagy supports cellular and organism homeostasis. However, whether autophagy should be inhibited or activated for cancer therapy remains unclear. Essential autophagy gene deletions increase the sensitivity of the mouse mammary carcinoma cells to radiation therapy in vitro and in vivo (in a syngeneic immunocompetent hosts). autophagy-deficient cells secreted increased amounts of type I interferon (IFN), which can be limited by CGAS or STING knockdown, depletion of mitochondrial DNA or mitochondrial outer membrane Permeabilisasi blockage via excess Bcl2 or BAX removal. In vivo, irradiated autophagy-competent mammary tumors induce strong immunity, which leads to an increase in lesion control nonirradiated away through type I IFN signaling systemic.

 Developmental data for several human mitochondrial DNA (mtDNA) long amplification targets
Developmental data for several human mitochondrial DNA (mtDNA) long amplification targets

Association of mitochondrial DNA copy number and rate of elimination with early pregnancy loss

early pregnancy loss (EPL) is a worldwide public events. Previous research suggests that mitochondrial DNA (mtDNA) copy number (CN) is associated with poor semen parameters and survival of preimplantation embryos, which shows the potential of mtDNA CN predictions for the results of an ongoing pregnancy.

However, no relevant studies have assessed the relationship between mtDNA CN and EPL. Thus, we aimed to determine whether mtDNA CN and 4977-bp mtDNA deletion rate (DR) in chorionic villi tissue associated with the EPL. Total DNA was extracted from the chorionic villi tissue of 75 cases of EPL and 75 healthy controls. chromosome analysis was performed using the copy number variation (CNV) sequencing. The mtDNA CN and DR is measured in a sample without pathogenic CNV. The relationship between mtDNA CN or DR and EPL risks were estimated using logistic regression.

Zenoprep Genomic DNA Purification Kit

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Zenoquick Viral DNA Purification Kit

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PCR DNA extraction and purification kit

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Plasmid DNA extraction and purification kit

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100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP 1/pk
EUR 73.00
Description: Bioscience Mol Bio; DNA Ladder

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Description: Bioscience Mol Bio; DNA Ladder

Genomic DNA Extraction and Purification

EP10012 100 Tests
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PCR DNA Extraction and Purification

EP10013 100 Tests
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Plasmid DNA Extraction and Purification

EP10014 100 Tests
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EpiNext DNA Purification HT System

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Mini Spincolumn for DNA Purification

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EUR 178.00

Mini Spincolumn for DNA Purification

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Cell & tissue genomic DNA extraction and purification kit

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Miniprep Kit For Plasmid DNA Extraction And Purification

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Miniprep Kit For Plasmid DNA Extraction And Purification

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Mini Spincolumn with lid for DNA Purification

S1920-250 250 column
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Mitochondrial DNA Isolation Kit

55R-1361 50 assays
EUR 825.00
Description: Mitochondrial DNA Isolation Kit for use in the research laboratory

Mitochondrial DNA Isolation Kit

K280-50
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Mitochondrial DNA Isolation Kit

K2117-50 50 assays
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T-Pro Gel/PCR DNA Purification Maxi Kit (10)

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  • EUR 272.00
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EUR 299.00
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EUR 485.00
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Lysosome Purification Kit

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RNA Purification Kit

MB1006-250preps 250 preps
EUR 397.00

RNA Purification Kit

MB1006-50preps 50 preps
EUR 166.00

Rapid Antibody Purification Kit

AKR-160 10 assays
EUR 519.00
Description: Cell Biolabs? Rapid Antibody Purification kit is designed for rapid, single-step purification of high-quality IgG from ascites, serum and tissue culture media or hybridoma supernatants.

His-tag Purification Kit

abx299036-4U 4 U
EUR 356.00
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MagSeq mRNA Purification Kit

K2012008 1 kit
EUR 360.00
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Adenovirus Mini Purification Kit

K1300-10
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R6111-050 50 prep
EUR 280.00

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R6111-200 200 prep
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ViraBind AAV Purification Kit

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EUR 711.00
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Human Mitochondrial DNA Copy Number Kit

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9K-006-0003 100preps
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  • Product category: Molecular Biology Kits/DNA - Extraction/PCR Products

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  • Product category: Molecular Biology Kits/DNA - Extraction/PCR Products

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MicroElute GEL Purification Kit (50prep)

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EZCatch? GST-Spin Purification Kit

K861-10
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Protein A Antibody Purification Kit

K974-10
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HDL Purification Kit (Ultracentrifugation Free)

STA-607 10 preps
EUR 432.00
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ViraBind AAV Purification Mega Kit

VPK-141 2 preps
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Exosome Purification and Detection Kit (Plasma)

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Protein A Spin Antibody Purification Kit

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LDL/VLDL Purification Kit (Ultracentrifugation Free)

STA-606 10 preps
EUR 432.00
Description: Ultracentrifugation of lipoproteins such as HDL, LDL and VLDL can be tedious and time consuming. The LDL/VLDL Purification Kit provides comparable purity without the need for an ultracentrifuge. Samples are separated into fractions containing LDL plus VLDL and then further purified using standard table-top centrifugation speeds.

ViraBind AAV Purification Kit, Trial Size

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EUR 380.00
Description: Purification of adeno-associated virus (AAV) using ultracentrifugation is tedious and time-consuming, and yields can be low. Our ViraBind AAV Purification Kits use a single-step proprietary purification matrix, followed by further purification and concentration with a centrifugal concentrator. The result is a higher viral yield with exceptional purity in a fraction of the time.

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Z1510001 5 ml
EUR 304.00
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SeqPure PCR Purification Kit, 50 ml

Z1510002 50 ml
EUR 899.00
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Z1510003 500 ml
EUR 5936.00
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Human DNA topoisomerase I, mitochondrial (TOP1MT) ELISA Kit

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Recombinant human DNA topoisomerase I, mitochondrial

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  • Uniprot ID: Q969P6
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
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  • Category: Cas9

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  • Category: Cas9

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  • Category: Cas9

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  • Category: Cas9

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  • Category: Cas9

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  • Category: Cas9

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Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

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  • Category: Cas9

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  • Category: Cas9

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Chicken Egg Yolk IgY antibody purification kit

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Exosome Purification and Detection Kit (Cell Culture)

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EUR 648.00
  • Shipped within 2-3 weeks.

After Tri-RNA Purification Mini Kit (50prep)

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96-well GEL Purification Kit (1 prep)

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EUR 213.00

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ToxOut? Protein A (Sepharose) Antibody Purification Kit

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ToxOut? Protein G (Sepharose) Antibody Purification Kit

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PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1)

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PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN340iPS-KIT 1 Kit
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COLD STORAGE / PURIFICATION STOCK SOLUTION

99-677-CM 1 L /pk
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Description: Specialty Media; Islet products

DNA-Directed RNA Polymerase, Mitochondrial (POLRMT) Antibody

20-abx217863
  • EUR 425.00
  • EUR 342.00
  • 100 ug
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DNA-Directed RNA Polymerase, Mitochondrial (POLRMT) Antibody

abx433157-200ul 200 ul
EUR 286.00
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Recombinant human DNA-directed RNA polymerase, mitochondrial

P2352 100ug Ask for price
  • Uniprot ID: O00411
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human DNA-directed RNA polymerase, mitochondrial

AAVS1 Safe Harbor Targeting Vector 2.0 - All-Purpose Donor (AAVS1-SA-puro-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE620A-KIT 1 kit
EUR 2132.00
  • Category: Gene Editing

AAVS1 Safe Harbor Targeting Vector 2.0 - GOI Knock-in Donor (AAVS1-SA-puro-EF1-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE622A-KIT 1 kit
EUR 2132.00
  • Category: Gene Editing

AAVS1 Safe Harbor Targeting Vector 2.0 - Reporter Knock-in Donor (AAVS1-SA-puro-MCS-GFP), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE624A-KIT 1 kit
EUR 2132.00
  • Category: Gene Editing

ELISA kit for Human DNA-directed RNA polymerase, mitochondrial (POLRMT)

KTE62351-48T 48T
EUR 332.00
  • Mitochondria of all organisms contain a genome that is distinct from that of the nucleus. The circular mitochondrial chromosome contains 37 genes that encode the RNA components of the mitochondrial translational apparatus, i.e., 22 transfer RNAs and
  • Show more
Description: Quantitative sandwich ELISA for measuring Human DNA-directed RNA polymerase, mitochondrial (POLRMT) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human DNA-directed RNA polymerase, mitochondrial (POLRMT)

KTE62351-5platesof96wells 5 plates of 96 wells
EUR 2115.00
  • Mitochondria of all organisms contain a genome that is distinct from that of the nucleus. The circular mitochondrial chromosome contains 37 genes that encode the RNA components of the mitochondrial translational apparatus, i.e., 22 transfer RNAs and
  • Show more
Description: Quantitative sandwich ELISA for measuring Human DNA-directed RNA polymerase, mitochondrial (POLRMT) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human DNA-directed RNA polymerase, mitochondrial (POLRMT)

KTE62351-96T 96T
EUR 539.00
  • Mitochondria of all organisms contain a genome that is distinct from that of the nucleus. The circular mitochondrial chromosome contains 37 genes that encode the RNA components of the mitochondrial translational apparatus, i.e., 22 transfer RNAs and
  • Show more
Description: Quantitative sandwich ELISA for measuring Human DNA-directed RNA polymerase, mitochondrial (POLRMT) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

EZ-10 Spin Column PCR Products Purification Kit

BS363 50Preps
EUR 76.64
  • Product category: Molecular Biology Kits/DNA - Extraction/PCR Products

EZ-10 Spin Column PCR Products Purification Kit

BS364 100preps
EUR 95.68
  • Product category: Molecular Biology Kits/DNA - Extraction/PCR Products

EZ-10 Spin Column PCR Products Purification Kit

BS664 250preps
EUR 166.58
  • Product category: Molecular Biology Kits/DNA - Extraction/PCR Products

ToxOutTM Protein A (Sepharose) Spin Antibody Purification Kit

K2504-5
EUR 648.00

ToxOut? Protein G (Sepharose) Spin Antibody Purification Kit

K2506-5
EUR 648.00

Adeno-associated Virus Mini Purification Kit, all serotypes

K1304-10
EUR 697.00

Adeno-associated Virus Mini Purification Kit, all serotypes

K1304-20
EUR 1153.00

EPL group had mtDNA CN significantly different (P <0.001) and DR (P = 0.005) compared with the control group. Both biomarkers are independent risk factors for EPL (CN odds ratio 1.71, 95% confidence interval 1.17 to 2.49, P = 0.005; DR odds ratio 1.07, 95% confidence interval 1.02 to 1.12 , P = 0.006). These results indicate that higher levels of mtDNA CN and DR strongly associated with the EPL and represent an independent risk factor for the EPL. Further studies validate these findings and to explore the biological mechanisms that underlie guaranteed.