New Evidence of Ancient Mitochondrial DNA of the Southern Andes (Calchaquí Valleys, Northwest Argentina, 3,600-1,900 Years before Present)
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New Evidence of Ancient Mitochondrial DNA of the Southern Andes (Calchaquí Valleys, Northwest Argentina, 3,600-1,900 Years before Present)
Genetic studies in the pre-Hispanic population of Southern Andes have risen steadily in the last decade. However, the characterization of ancient DNA Formative Period archaeological remains of humans is lacking, especially for Northwest Argentina.
To expand the current information on the genetic characterization of the first farming communities of southern Calchaquí Valleys, we present and discuss the first ancient mitochondrial DNA information obtained on the sample dates to ca. 3.600 to 1.900 years before present from Cajon Valley, Catamarca Province. Reproduced mtDNA hypervariable region 1 (HVR-1) was obtained in seven individual sequences. Mitochondria HVR-1 haplotype assigned to three of the four founding haplogroups, D1 (57.1%), C1 (28.5%), and B2 (14.2%), in the absence of A2.
Our results indicate that the Cajon Valley of the sample, with a predominance of D1 and C1, is different from that commonly seen in ancient and modern Andean populations, which usually indicates a high prevalence of haplogroup B2. The fact that Cajon Valley and Pampa Grande (Salta Province, Argentina) shared the prevalence of haplogroup D1 can provide additional evidence to support the genetic affinity may be between the valleys and the sub-Andean region of the east during the Period Formative in Northwest Argentina, expand the archaeological evidence of contacts between the two population. Future full mitogenomic analysis will provide important information to formulate new hypotheses on the origin and phylogenetic relationships between individuals from Cajon Valley and other groups of the Andes, the Gran Chaco, and the Amazon.
Although recent studies suggest the involvement of monocytes to accelerate lesion formation neuromyelitis optica spectrum disorders (NMOSD), the exact mechanism of activation of the innate immune system remains elusive. Thus, in this study, we aimed to clarify the mechanism of pathogenesis NMOSD from the standpoint of innate immune activation. We established a recombinant anti-AQP4 autoantibodies (Ab) of plasmablasts in CSF NMOSD patients. Human astrocytes were treated with anti-AQP4 Ab produce large amounts of CCL2 and contributing to the efficient recruitment of monocytes.
New Evidence of Ancient Mitochondrial DNA of the Southern Andes (Calchaquí Valleys, Northwest Argentina, 3,600-1,900 Years before Present)
Disadvantages relationship between mitochondrial DNA haplogroup J and T and clinical manifestations in patients with Brugada syndrome Russia
Brugada Syndrome (BRS) is a congenital disorder characterized by specific ST segment elevation in the right precordial leads, pseudo right bundle branch block, and a high risk of sudden cardiac death due to ventricular tachycardia. Was originally described as a monogenic disorder with an autosomal dominant mode of inheritance.
It is hypothesized that modifying the genetic factors, in addition to disease-causing mutations, can significantly contribute to the clinical symptoms and the risk of sudden cardiac death. Modifying factors may include mitochondrial DNA (mtDNA) variants. In particular, the combination of mtDNA m.T4216C, m.A11251G, m.C15452A and variants m.T16126C (defining haplogroup T and J), considered to be a factor that promotes the manifestation of BRS manifestations, without pro-arrhythmic effect.
Should the Human Polymerase DNA Directed Gamma 1 (POLg1) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Polymerase DNA Directed Gamma 1 (POLg1) in samples from tissue homogenates, cell lysates or other biological fluids.
Human Polymerase DNA Directed Gamma 1 (POLg1) ELISA Kit
Should the Human Polymerase DNA Directed Gamma 1 (POLg1) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Polymerase DNA Directed Gamma 1 (POLg1) in samples from tissue homogenates, cell lysates or other biological fluids.
Human Polymerase DNA Directed gamma 1 (POLg1) ELISA Kit
The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Polymerase DNA Directed Gamma 1 (POLg1) were tested on 3 different plates, 8 replicates in each plate
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Polymerase DNA Directed Gamma 1 (POLg1) in Tissue homogenates, cell lysates and other biological fluids.
Human Polymerase DNA Directed Gamma 1 (POLg1) ELISA Kit
The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Polymerase DNA Directed Gamma 1 (POLg1) were tested on 3 different plates, 8 replicates in each plate
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Polymerase DNA Directed Gamma 1 (POLg1) in Tissue homogenates, cell lysates and other biological fluids.
Human Polymerase DNA Directed Gamma 1 (POLg1) ELISA Kit
The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Polymerase DNA Directed Gamma 1 (POLg1) were tested on 3 different plates, 8 replicates in each plate
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Polymerase DNA Directed Gamma 1 (POLg1) in Tissue homogenates, cell lysates and other biological fluids.
Human Polymerase DNA Directed Gamma 1 (POLg1) ELISA Kit
The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Polymerase DNA Directed Gamma 1 (POLg1) were tested on 3 different plates, 8 replicates in each plate
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Polymerase DNA Directed Gamma 1 (POLg1) in Tissue homogenates, cell lysates and other biological fluids.
Human Polymerase DNA Directed Gamma 1 (POLg1) ELISA Kit
Known also as Polymerase DNA Directed Gamma 1 elisa. Alternative names of the recognized antigen: PEO
POLG1
POLGA
SANDO
SCAE
Mitochondrial DNA polymerase catalytic subunit
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Polymerase DNA Directed Gamma 1 (POLg1) in samples from Tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.
DNA polymerase epsilon (POLE) has been implicated in DNA repair and replication. Purified human HeLa POLE consists of a 261-kD catalytic subunit and a 55-kD accessory subunit. Li et al. (1997) cloned the small subunit of human POLE, which they symbol
Description: Quantitative sandwich ELISA for measuring Bovine DNA polymerase epsilon subunit 2 (POLE2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Bovine DNA polymerase epsilon subunit 2 (POLE2)
DNA polymerase epsilon (POLE) has been implicated in DNA repair and replication. Purified human HeLa POLE consists of a 261-kD catalytic subunit and a 55-kD accessory subunit. Li et al. (1997) cloned the small subunit of human POLE, which they symbol
Description: Quantitative sandwich ELISA for measuring Bovine DNA polymerase epsilon subunit 2 (POLE2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Bovine DNA polymerase epsilon subunit 2 (POLE2)
DNA polymerase epsilon (POLE) has been implicated in DNA repair and replication. Purified human HeLa POLE consists of a 261-kD catalytic subunit and a 55-kD accessory subunit. Li et al. (1997) cloned the small subunit of human POLE, which they symbol
Description: Quantitative sandwich ELISA for measuring Bovine DNA polymerase epsilon subunit 2 (POLE2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Human DNA-directed RNA polymerase III subunit RPC1 (POLR3A)
Description: High quality RedTaq polymerase for different PCR variations and downstream applications.
The purpose of this study is to confirm the association reported to BRS with mtDNA variants in the group of patients Russia. mtDNA haplogroup genotyped in 47 probands BRS Russia and the prevalence of mtDNA haplogroups common than the general population in the European part of Russia. Distribution and prevalence of all but the mtDNA haplogroup J BRS comparable in probands and general Russian population. Mitochondrial haplogroup J was not found in the BRS cohort. In conclusion, it was shown that mtDNA polymorphisms, m.T4216C (haplogroup J and T) does not contribute significantly to the clinical manifestations in patients BRS Russia.
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DNA Polymerase gamma antibody 
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Monoclonal Anti-Human DNA Polymerase gamma antibody # 1  Protein)
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ELISA kit for Bovine DNA polymerase epsilon subunit 2 (POLE2) )
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